The following airlines serve the Mactan-Cebu International Airport (as of February 2008):

Cánh nội địa

• Asian Spirit (Malay)
• Cebu Pacific (Bacolod, Butuan, Cagayan de Oro, Davao, Iloilo, Manila, Manila-Clark, Puerto Princesa, Zamboanga)
• Philippine Airlines (Manila)
  • Air Philippines (Bacolod, Davao, General Santos, Iloilo, Malay, Tacloban)
• South East Asian Airlines (Cotabato, Malay, Manila-Clark, Mambajao)

Cánh quốc tế

• Asiana Airlines (Seoul-Incheon)
• Cathay Pacific (Hong Kong)
• Cebu Pacific (Bangkok-Suvarnabhumi [từ ngày 06.04.08], Busan, Hong Kong, Seoul-Incheon, Singapore, Taipei-Taiwan Taoyuan)
• China Airlines
  • Mandarin Airlines (Kaohsiung, Taipei-Taiwan Taoyuan)
• China Eastern Airlines (Shanghai-Pudong)
• Korean Air (Seoul-Incheon)
• Malaysia Airlines (Kota Kinabalu, Kuala Lumpur)
• Philippine Airlines (Seoul-Incheon, Tokyo-Narita)
• Qatar Airways (Doha)
• Singapore Airlines
  • SilkAir (Singapore)
• South East Asian Airlines (Semarang)

Các hãng trước đây

• Aerolift Philippines
• China Southern Airlines
• Continental Micronesia
• DragonAir
• Gulf Air
• Grand Air International
• Mindanao Express
• Singapore Airlines